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3X4 Genetics vs 23andMe: A Smarter Way to Decode Your Health

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You’ve probably seen the ads — “Discover your ancestry. Unlock your health. Know your DNA.”Direct-to-consumer DNA tests like 23andMe and AncestryDNA are great for learning about your origins, but when it comes to understanding how your body actually works, they only scratch the surface.

We use 3X4 Genetics, an advanced, practitioner-guided genetic test designed for functional health optimization — not just ancestry insights.
Instead of telling you where you came from, 3X4 helps you understand how your body functions and what you can do to optimize it.

Think of it this way:

  • Consumer tests show you your story.
  • 3X4 Genetics helps you take charge of it.

Functional Health vs. Genetic Curiosity

Aspect

3X4 Genetics

23andMe/ AncestryDNA

Why It Matters

Primary Goal

Functional wellness and personalized health optimization

Ancestry mapping and general curiosity

3X4 is designed to improve how your body performs, not just trace your roots.

Interpretation Model

Pathway-based — analyzes how genes interact across 36 biological systems

Variant-based — lists single SNPs and probability traits

Pathway analysis gives clinically meaningful insights.

Oversight

Ordered and interpreted by certified health practitioners

Fully direct-to-consumer, self-interpreted

Practitioner involvement ensures results are medically responsible.

Outcome

Personalized nutrition, fitness, and lifestyle guidance

Informational reports for general education

3X4 turns DNA into actionable health strategies.

Summary:

  • Consumer tests give you data.
  • 3X4 Genetics helps you apply it.

How 3X4 Genetics Works

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3X4 Genetics uses a pathway-based model, studying how groups of genes influence the body’s key systems — metabolism, inflammation, detoxification, hormones, cardiovascular function, cognition, and stress response.

Rather than focusing on single genetic markers, it interprets how your 157 genes work together to shape your energy, resilience, and longevity.
This systems-level insight helps practitioners craft a personalized plan that supports how your body actually functions day to day.

Clinical Interpretation and Support

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Unlike direct-to-consumer tests, 3X4 results are reviewed by a certified practitioner trained in genetics and functional medicine.
Your consultation connects your unique genetic profile with your current symptoms, goals, and lifestyle, transforming complex data into practical, measurable changes.

Your personalized recommendations may include guidance for:

  • Nutrition and meal planning
  • Detoxification support
  • Exercise and recovery
  • Stress resilience and sleep optimization

Every plan is designed to help you feel and perform better — safely, effectively, and uniquely for you.

From Data to Action: What Makes It Different

Many DNA kits stop at “you may have a higher likelihood of…”
3X4 goes further, showing you why that’s happening — and what to do about it.

Your report delivers insights that connect directly to your lifestyle, helping you optimize:

  • Metabolism and weight management
  • Hormonal and energy balance
  • Cognitive performance and mental clarity
  • Detox and inflammation pathways

Each recommendation is grounded in science and interpreted by a professional — not a computer algorithm.

Quality Over Quantity: The 157-Gene Advantage

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While some genetic tests assess hundreds of thousands of SNPs for ancestry purposes, 3X4 focuses on 157 curated, clinically validated genes that directly influence wellness and performance.
By narrowing the scope to genes that truly matter, 3X4 delivers precise, actionable, and meaningful data — without the noise.

This “quality-over-quantity” approach ensures your results are accurate, clear, and relevant to your everyday health goals.

Data Privacy and Ethical Integrity

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Your privacy matters.
3X4 Genetics follows strict data-protection and confidentiality standards, maintaining compliance with HIPAA and international privacy frameworks. Your sample is processed securely in accredited labs and never sold or shared for marketing or research purposes.

Unlike many consumer DNA tests, your data with 3X4 remains yours — used only to inform your health and wellness plan.

Science-Based, Wellness-Focused

3X4 Genetics is not a diagnostic or disease-screening tool.

Instead, it’s a functional wellness test — using validated gene-function research to show how your body manages inflammation, energy production, detoxification, and nutrient metabolism.

This approach aligns with the latest trends in personalized medicine, giving you a deeper understanding of how your genetics influence your long-term health.

Practitioner-Guided Experience at Holistic Medical Wellness

Your genetic testing journey is simple and personalized:

  1. Order your 3X4 test kit — an easy, at-home cheek swab.
  2. Register and send your sample to our certified lab.
  3. Receive results in 3–4 weeks.
  4. Meet with your practitioner for a personalized report and wellness roadmap.

The test is also eligible for HSA/FSA reimbursement, making it more accessible for those investing in long-term preventive health.

Who Benefits Most

3X4 Genetics is ideal for individuals who:

  • Struggle with fatigue, slow metabolism, or inflammation.
  • Want to optimize performance and longevity.
  • Are proactive about personalized wellness and prevention.
  • Prefer actionable insights over generic advice.

This test empowers you with information to make smarter choices about nutrition, fitness, and lifestyle — supported by professional guidance.

FAQs

 

3X4 Genetics is a practitioner-guided DNA test that analyzes 157 genes to understand how your body functions across key pathways — including metabolism, inflammation, detoxification, hormone balance, and energy production. It provides actionable, personalized recommendations for nutrition, fitness, and wellness.

 

23andMe and AncestryDNA focus mainly on ancestry and general genetic traits for consumer interest. 3X4 Genetics, on the other hand, is a functional health test interpreted by certified practitioners. It focuses on how your genes work together and how to optimize your wellness through personalized, evidence-based strategies.

 

No. 3X4 Genetics is not diagnostic and does not detect or diagnose medical conditions. It is a functional wellness test used to help practitioners design personalized lifestyle and nutrition plans for long-term health optimization.

 

This test is ideal for anyone seeking a deeper understanding of their body and looking to enhance health, performance, or longevity. It’s especially helpful for individuals with chronic fatigue, inflammation, slow metabolism, hormonal imbalances, or those who simply want to take a proactive approach to wellness.

 

The process is simple and non-invasive. You’ll receive a cheek-swab kit that can be completed at home. After mailing your sample to the certified lab, results are typically ready within 3–4 weeks, followed by a personalized consultation with your practitioner.

 

 

While traditional insurance typically does not cover genetic wellness testing, 3X4 Genetics is eligible for HSA and FSA reimbursement, making it accessible for individuals investing in preventive and functional healthcare.

 

3X4 Genetics follows strict scientific and privacy standards, including HIPAA compliance for data protection. The laboratory uses validated genetic markers and pathway-based models to ensure accurate, evidence-driven insights. Your data and sample remain private and are never sold or shared.

Your DNA Is a Blueprint for Better Health

Your DNA holds incredible insight — but information alone isn’t transformation.
While consumer DNA tests reveal where you came from, 3X4 Genetics shows how your body functions and what you can do to support it.

Our goal is to help you move from information to action — turning your genetic potential into lasting wellness.

Your body already has the blueprint.

3X4 Genetics helps you read it — and live it.

Legal & Medical Disclaimer

The information provided on this blog and website is for informational and educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or another qualified health provider with any questions you may have regarding a medical condition, diagnosis, or treatment plan. Do not disregard or delay professional medical advice because of information you have read on this website.

The content presented may include discussions of wellness therapies, dietary supplements, compounded medications, functional medicine services, and other integrative or alternative treatments that are not evaluated or approved by the U.S. Food and Drug Administration (FDA). These services and products are not intended to diagnose, treat, cure, or prevent any disease.

The content is provided “as is,“ without warranties of any kind, either express or implied. While we strive to ensure accuracy, we make no guarantees regarding the completeness, timeliness, or accuracy of the information presented. The website and its authors disclaim any liability for errors, omissions, or outcomes related to the use of the information provided.

Reference to any specific tests, products, procedures, healthcare professionals, or opinions is not an endorsement or recommendation unless explicitly stated. Links to external websites are provided for convenience and do not constitute an endorsement or guarantee of the content contained therein.

Your use of this website constitutes your acceptance of this disclaimer and any future modifications. If you do not agree, please do not use the site.

This disclaimer shall be governed by and construed in accordance with the laws of the State of Florida, without regard to conflict of law principles
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Article Written By

Richard Koffler, MD

NPI Number- 1467557264
  • Dr. Koffler is a Physiatrist, specializing in Physical Medicine & Rehabilitation.
  • Graduated from the Sackler School of Medicine at Tel Aviv University in 1993 Dr. Koffler completed a one-year internship in internal medicine at Roosevelt Hospital in New York City.
  • Residency in Physical Medicine and Rehabilitation at the Rusk Institute at NYU Medical Center in New York City. Board certified in 1998.
  • Trained in acupuncture at Helms Medical Institute at UCLA His medical practice incorporates proven conventional western medicine integrating eastern alternative practices.
  • Medical Director of several medical clinics in NYC, Stamford CT, and Miami Beach, FL.
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